Publications

Books

A.S. Bommarius and B.R. Riebel, “Biocatalysis – Fundamentals and Applications”, Wiley-VCH, 2004, ISBN: 3-527303-448

Refereed Papers
  1. J. Rubin, L. Linden, W.M. Coco, A.S. Bommarius, S.H. Behrens, “Salt-Induced Aggregation of a Monoclonal Human Immunoglobulin G1”, J. Pharm. Sci. 2013102, 377-386

  2. M.J. Abrahamson, J.W. Wong, A.S. Bommarius, “The rapid evolution of an amine dehydrogenase biocatalyst for the asymmetric production of chiral amines“ , Adv. Synth. Catal.2013,355, 1780-1786

  3. A.S. Bommarius and M.F. Paye, “Stabilizing biocatalysts”, Chemical Society Reviews 201342 (15), 6534-6565 (Special Issue: Enzyme Immobilization), eds.: Ulf Hanefeld, Linqiu Cao

  4. Y. Kang, P. Bansal, M.J. Realff, A.S. Bommarius, “SO2-Catalyzed Steam Explosion: The Effects of Different Severity on Digestibility, Accessibility and Crystallinity of Lignocellulosic Biomass”, Biotechnol. Progress 201329, 909-916

  5. J.K. Blum, W.D. Ricketts, and A.S. Bommarius, “Improved thermostability of amino ester hydrolase (AEH) by combining B-FIT analysis and structure-guided consensus method”, J. Biotechnol. 2012, 160, 214-221

  6. M.J. Abrahamson, E. Vazquez-Figueroa, N.B. Woodall, J.C. Moore, A.S. Bommarius, “Development of a Novel Amine Dehydrogenase for Synthesis of Chiral Amines“, Angew. Chem. Intl. Ed. 2012, 51, 3969-3972

  7. A.L. Deaguero, J.K. Blum, and A.S. Bommarius, “Improving the Diastereoselectivity of Penicil-lin G Acylase for Ampicillin Synthesis from Racemic Substrates”, Prot. Eng. Des. Select. 2012, 25, 135-144

  8. P. Bansal, B.J. Vowell, M. Hall, M.J. Realff, J.H. Lee, A.S. Bommarius, “Elucidation of Cellulose Accessibility, Hydrolysability and Reactivity as the Major Limitations in the Enzymatic Hydrolysis of Cellulose”, Biores. Technol. 2012, 107, 243-250

  9. H.S. Castillo, A.M. Ousley, A. Duraj-Thatte, K.N. Lindstrom, D.D. Patel, A.S. Bommarius, B. Azizi, “The Role of Residue C410 on Activation of the Human Vitamin D Receptor by Various Ligands”, J. Steroid Biochem. Mol. Biol. 2012, 128, 76-86

  10. H. Shaffer, E. Chang, A. Bommarius, D. Doyle, B. Azizi, “BAPJ69-4A: A Yeast Two-Hybrid Strain for Both Positive and Negative Genetic Selection”, FEBS J., in press

  11. M. Hall, J. Rubin, S.H. Behrens, and A.S. Bommarius, “The Cellulose-Binding Domain of Cellobiohydrolase Cel7A from Trichoderma reesei Is Also a Thermostabilizing Domain”, J. Biotechnol. 2011, 155, 370-376

  12. M. Hall and A. S. Bommarius, "Enantioenriched compounds via enzyme-catalyzed redox reactions”, Chem. Rev. 2011, 111, 4088-4110

  13. J.T. Park, J.I. Hirano, V. Thangavel, B.R. Riebel, A.S. Bommarius, “NAD(P)H oxidase V from Lactobacillus plantarum V (NoxV) displays enhanced operational stability even in absence of reducing agents”, J. Mol. Catal. B Enz. 2011, 71, 159-165

  14. Y. Yanto, C. K. Winkler, S.J. Lohr, M. Hall, K. Faber, and A.S. Bommarius, “Asymmetric Bioreduction of Alkenes Using Ene Reductases YersER and KYE1, and Effects of Organic Solvents”, Org. Lett., 2011, 13, 2540-43

  15. R.B. Vegh, K.M. Solntsev, M.K. Kuimova, S.H. Cho, Y.A. Liang, B.L.W. Loo, L.M. Tolbert, and A.S. Bommarius, “Reactive Oxygen Species in the Photochemistry of the Fluorescent Protein “Killer Red” “, Chem. Comm. 2011, 47, 4887-4889

  16. A.S. Bommarius, J.K. Blum, and M.J. Abrahamson, “Status of Protein Engineering for Bio-catalysts: How to design an industrially useful biocatalyst”, Curr. Opin. Chem. Biol. 2011, 15, 194-200 

  17. M. Hall, P. Bansal, J.H. Lee, M.J. Realff, A.S. Bommarius, “Biological pretreatment of cellulose: Enhancing enzymatic hydrolysis rate using cellulose-binding domains from cellulases”, Biores. Technol. 2011, 102, 2910-15

  18. ERRATUM: “Correlating aggregation kinetics and stationary diffusion in protein- sodium salt systems observed with dynamic light scattering”, J. Rubin, A. San Miguel, A.S. Bommarius, S.H. Behrens, J. Phys. Chem. B 2011, 115, 10778-78

  19. M.R. Prausnitz and A.S. Bommarius, “Drug Design, Development, and Delivery: An Interdisciplinary Course on Pharmaceuticals”, J. Chem. Eng. Educ. 2011, 45, 47-52

  20. J.K. Blum and A.S. Bommarius, “Amino Ester Hydrolase from Xanthomonas campestris pv. campestris, ATCC 33913 for Enzymatic Synthesis of Ampicillin”, J. Mol. Catal. B: Enzymatic 2010, 67, 21-28

  21. J.K. Blum, A.L. Deaguero, C.V. Perez, and A.S. Bommarius, „"Ampicillin synthesis using a two-enzyme cascade with both alpha-Amino Ester Hydrolase and Penicillin G Acylase", ChemCatChem 2010, 2, 987-991

  22. M. Hall, Y. Yanto, and A.S. Bommarius, ‘Old Yellow Enzyme’ family and Enoate Reductases: Asymmetric Reduction of C=C Bonds and Activity on Nitro Compounds, The Encyclopedia of Industrial Biotechnology: Bioprocess, Bioseparation, and Cell Technology (ed; M. Flickinger), Wiley, 2010, 2234-2247

  23. A.L. Deaguero, J.K. Blum, A.S. Bommarius, Biocatalytic synthesis of beta-lactam antibiotics, The Encyclopedia of Industrial Biotechnology: Bioprocess, Bioseparation, and Cell Technology (ed; M. Flickinger), Wiley, 2010, 535-567

  24. Y. Yanto, M. Hall, and A.S. Bommarius, Nitroreductase from Salmonella typhimurium: characterization and catalytic activity, Org. Biomol. Chem. 2010, 8, 1826-1832

  25. J. Rubin, A. San Miguel, A.S. Bommarius, S.H. Behrens, Correlation of aggregation kinetics and stationary diffusion in protein - sodium salt systems observed with dynamic light scattering, J. Phys. Chem. B 2010, 114, 4383-4387

  26. P. Bansal, M. Hall, M.J. Realff, J.H. Lee, and A.S. Bommarius, Multivariate statistical analysis of X-ray data from cellulose: A new method to determine degree of crystallinity and predict hydrolysis rates, Bioresource Technol. 2010, 101, 4461-4471

  27. V. Yeh, J.M. Broering, B. Chen, A. Romanyuk, Y.O. Chernoff, A.S. Bommarius, The Hofmeister effect on Amyloid Formation Using Yeast Prion Protein, Protein Science 2010, 19, 47-56

  28. T.A. Rogers and A.S. Bommarius, Utilizing Simple Biochemical Measurements to Predict Lifetime Output of Biocatalysts in Continuous Isothermal Processes, Chem. Eng. Sci. 2010, 65, 2118-2124

  29. M. Hall, P. Bansal, J.H. Lee, M.J. Realff, and A.S. Bommarius, Cellulose Crystallinity: a Key Predictor of Enzymatic Hydrolysis Rate, FEBS J. 2010, 277, 1571-1582

  30. P. Bansal, M. Hall, M. J. Realff, J. H. Lee, A. S. Bommarius. Modeling Cellulase Kinetics on Lignocellulosic Substrates. Biotechnol. Adv. 2009, 27, 833-848.

  31. T. A. Rogers, R. M. Daniel, A. S. Bommarius, “Deactivation of TEM-1 b -lactamase investigated by isothermal batch and non-isothermal continuous enzyme membrane reactor methods”, ChemCatChem 2009, 1, 131-137.

  32. B.L.W. Loo, A. Dubey, M.J. Realff, J.H. Lee, and A.S. Bommarius, “Analysis of recombinant sequences for interacting residues can improve the quality of combinatorial library: case study on fluorescent proteins”, Biotech. J. 2008, 3, 63-73

  33. A.S. Bommarius, Adrian Katona, Sean E. Cheben, Arpit S. Patel, Arthur J. Ragauskas, Kristina Knudson, and Yunqiao Pu, “Cellulase kinetics as a function of cellulose pretreatment”, Metab. Eng. 2008, 10, 370-381

  34. J.M. Broering and A.S. Bommarius, “A kinetic model for salt-induced protein deactivation”, J. Phys. Chem. B. 2008, 112, 12768–12775

  35. N. Kothari, A.A. Jafarpour, R.P. Trebino, T.L. Thaler, A.S. Bommarius, “Astrobiological polarimeter”, Astrobiology 2008, 8, 1061-1069.

  36. E. Vázquez-Figueroa, V. Yeh, J.M. Broering, J.F. Chaparro-Riggers, and A.S. Bommarius, “Thermostable Variants Constructed via the Structure-guided Consensus Method also Show Increased Stability in Salt Solutions and Homogeneous Aqueous-Organic Media”, Protein Eng. Des. Sel. 2008, 21, 673-680

  37. J.F. Chaparro-Riggers, K.M. Polizzi, E. Vazquez-Figueroa, T.A. Rogers, and A.S. Bommarius, “Comparison of three Enoate Reductases and their potential use for biotransformations”, Adv. Synth. Catal. 2007, 349, 1521-1531

  38. J.M. Broering and A.S. Bommarius, “Cation and strong cosolute effects on protein kinetic stability”, Biochem. Soc. Trans. 2007, 35, 1602-5.

  39. E. Vazquez-Figueroa, J.F. Chaparro-Riggers, and A.S. Bommarius, “Development of a Thermostable Glucose Dehydrogenase via a Structure-guided Consensus Concept”, ChemBioChem 2007, 8, 2295-2301.

  40. J.F. Chaparro-Riggers, B.L.W. Loo, K.M. Polizzi, P.R. Gibbs, X.-S. Tang, M.J. Nelson, and A.S. Bommarius, „Revealing Biases Inherent in Recombination Protocols“, BMC Biotechnology 2007, 7, 77

  41. E.M. Hill, J.M. Broering, J.P. Hallett, C.L. Liotta, C.A. Eckert, and A.S. Bommarius, “Coupling Chiral Homogeneous Biocatalysis with Benign Heterogeneous Separation”, Green Chemistry 2007, 9, 888-893

  42. K.M. Polizzi, D.A. Moore, and A.S. Bommarius, “A short-chain dehydrogenase/reductase from Vibrio vulnificus with both blue fluorescence and oxidoreductase activity”, Chem. Comm. 2007, 1843-5

  43. K.M. Polizzi, A.S. Bommarius, J.M. Broering, J.F. Chaparro-Riggers, “Stability of enzymes”, Curr. Opin. Chem. Biol. 2007, 11, 220-225

  44. J.F. Chaparro-Riggers, K.M. Polizzi, A.S. Bommarius, “Better library design: data-driven protein engineering”, Biotechnol. J. 2007, 2, 180-191

  45. T.L. Thaler, P.R. Gibbs, R.P. Trebino, and A.S. Bommarius, “Search for Extraterrestrial Life Using Chiral Molecules: Mandelate Racemase as a Test Case”, Astrobiology 2006, 6, 910-920

  46. A.S. Bommarius, J.M. Broering, J.F. Chaparro-Riggers and K.M. Polizzi, “High-Throughput Screening for enhanced stability of proteins” , Curr. Opin. Biotechnology 2006, 18, 606-610

  47. A. Dubey, M.J. Realff, J.H. Lee, and A.S. Bommarius, “Identifying the Interacting Positions of a Protein using Boolean learning and Support Vector Machines”, Comp. Biol. Chem. 2006, 30, 268-279

  48. G.T. Lountos, R. Jiang, W.B. Wellborn, T.L. Thaler, A.S. Bommarius and A.M. Orville, “The Crystal Structure of NAD(P)H Oxidase from Lactobacillus sanfranciscensis: Insights into the Conversion of O2 into Two Water Molecules by the Flavoenzyme“, Biochemistry 2006, 45, 9648-9659

  49. K.M. Polizzi, M. Parikh, C.U. Spencer, I. Matsumura, J.H. Lee, M.J. Realff, and A.S. Bommarius, “Pooling for Improved Screening of Combinatorial Libraries for Directed Evolution” , Biotechnol. Progr. 2006, 22, 961-967

  50. J.M. Broering, E.M. Hill, J.P. Hallett, C.L. Liotta, C.A. Eckert, and A.S. Bommarius, "Biocatalytic reaction and recycle using CO2-induced Organic Aqueous Tunable Solvents (OATS)", Angew. Chem. Intl. Ed. 2006, 45, 4670-4673

  51. K.M. Polizzi&, J.F. Chaparro-Riggers&, E. Vazquez-Figueroa, and A.S. Bommarius, “Structure-guided consensus approach to create a more thermostable penicillin G acylase”, Biotechnology J. 2006, 1, 531-536

  52. A.S. Bommarius and K.M. Polizzi, “Novel biocatalysts: recent developments”, Chem. Eng. Sci. 2006, 61, 1004-1016

  53. K.M. Polizzi, C.U. Spencer, A. Dubey, I. Matsumura, J.H. Lee, M.J. Realff, and A.S. Bommarius, “Simulation modeling of pooling for combinatorial protein engineering”, J. Biomol. Screening, 2005, 10, 856-864

  54. A.S. Bommarius and A. Karau, “Deactivation of formate dehydrogenase (FDH) in solution and at gas-liquid interfaces”, Biotechnol. Progr. 2005, 21, 1663-1672

  55. J.M. Broering and A.S. Bommarius, „Evaluation of Hofmeister effects on the kinetic stability of proteins“, J. Phys. Chem. B 2005, 109, 20612-19

  56. A.S. Bommarius and J.M. Broering, ““Established and novel tools to investigate biocatalyst stability”, Biocatalysis and Biotransformation 2005, 23, 125-139

  57. R. Jiang, B.R. Riebel and A.S. Bommarius, “Comparison of competing oxygen reduction pathways in Lactococcus lactis: four-electron vs. two-electron reduction by NADH oxidases”, Adv. Synth. Cat. 2005, 347, 1139-1146

  58. P.R. Gibbs, C.S. Uehara, U. Neunert, and A.S. Bommarius, “Accelerated biocatalyst stability testing for process optimization”, Biotech. Progr. 2005, 21, 762-774

  59. A. Dubey, M.J. Realff, J.H. Lee, and A.S. Bommarius, “Support Vector Machines for Predicting the Critical Positions of a Protein”, J. Theor. Biol. 2005, 234, 351-361

  60. G.T. Lountos, B.R. Riebel, W.B. Wellborn, A.S. Bommarius, A.M. Orville, "Crystallization and Preliminary Analysis of a Water-Forming NADH Oxidase from Lactobacillus sanfranciscensis", Acta Cryst. D, 2004, 60, 2044-47

  61. R. Jiang and A.S. Bommarius, "Hydrogen peroxide-producing NADH oxidase (nox 1) from Lactococcus lactis", Tetrah. Asymm. 2004, 15, 2939-44

  62. P. Ödman, W.B. Wellborn, A.S. Bommarius, "An enzymatic process to -ketoglutarate from L-glutamate: the coupled system L-glutamate dehydrogenase/NADH oxidase", Tetrah. Asymm. 2004, 15, 2933-37

  63. J. Lu, M.J. Lazzaroni, J.P. Hallett, A.S. Bommarius, C.L. Liotta, and C.A. Eckert, "Tunable Solutions for Homogeneous Catalyst Recycle", I&EC Research 2004, 43, 1586-1590

  64. B.R. Riebel, P.R. Gibbs, W.B. Wellborn, and A.S. Bommarius, "Cofactor regeneration of both NAD+ from NADH and NADP+ from NADPH: NADH oxidase from Lactobacillus sanfranciscensis", Adv. Synth. Cat., 2003, 345, 707-712

  65. B.R. Riebel, P.R. Gibbs, W.B. Wellborn, and A.S. Bommarius, "Cofactor regeneration of NAD+ from NADH: novel water-forming NADH oxidases", Adv. Synth. Cat., 2002, 344, 1156-1169

  66. O. May, S. Verseck, A.S. Bommarius, and K. Drauz, "Development of Dynamic Kinetic Resolution Processes for Biocatalytic Production of Natural and Nonnatural L-Amino Acids", Organic Process Research & Development. 2002, 6, 452-457

  67. J. Wöltinger, K. Drauz and A. S. Bommarius, "The Membrane Reactor in the Fine Chemicals Industry", Appl. Catalysis A: General. 2001, 221, 171–185

  68. S. Verseck, A.S. Bommarius and M.-R. Kula, "Screening, Overexpression and Characterization of an N-Acylamino Acid Racemase from Amycolatopsis orientalis subsp. lurida", Appl. Microbiol. Biotechnol. 2001, 55, 354-361

  69. A.S. Bommarius, M. Schwarm and K. Drauz, "Comparison of Different Chemoenzymatic Process Routes to Enantiomerically Pure Amino Acids", Chimia 2001, 55, 50-59

  70. J. Wöltinger, H. Henniges, A.S. Bommarius, H.-P. Krimmer and K. Drauz, "Application of the continuous Sharpless-dihydroxylation", Tetrahedron Asymmetry 2001, 12, 2095-2098

  71. J. Wöltinger, A.S. Bommarius, K. Drauz and C. Wandrey, "The Chemzyme Membrane Reactor in the Fine Chemicals Industry", Organic Process Research & Development, 2001, 5, 241-248

  72. A.S. Bommarius, K. Drauz, S. Eils, J. Kirchhoff and M. Schwarm, "Reduction Technologies in the Industrial Synthesis of Fine Chemicals", Chimica Oggi 2000, 18, 12-17

  73. A.S. Bommarius, M. Schwarm and K. Drauz, "Biocatalysis to Amino Acid-based Chiral Pharmaceuticals - Examples and Perspectives", J. Mol. Cat B: Enzymatic 1998, 5, 1-11

  74. U. Eichhorn, A.S. Bommarius, K. Drauz and H.-D. Jakubke, "Synthesis of dipeptides by suspension-to-suspension conversion via thermolysin catalysis - from analytical to preparative scale", J. Peptide Science 1997, 3, 245-251

  75. G. Krix, A.S. Bommarius, K. Drauz, M. Kottenhahn, M. Schwarm and M.-R. Kula, "Enzymatic reduction of a-keto acids leading to L-amino acids or D-hydroxy Acids", J. Biotechnology 1997, 53, 29-39;

  76. A.S. Bommarius, K. Drauz, K. Günther, G. Knaup and M. Schwarm, "L-Methionine Related L-Amino Acids by Acylase Cleavage of Their Corresponding N-Acetyl-DL-Derivatives", Tetrahedron Asymmetry 1997, 8, 3197-3200

  77. U. Stelkes-Ritter, G. Beckers, A.S. Bommarius, K. Drauz, K. Günther, M. Kottenhahn, M. Schwarm and M.-R. Kula, "Kinetics of peptide amidase and its application for the resolution of racemates", Biocatalysis and Biotransformations 1997, 15, 205-219

  78. A.S. Bommarius, M. Schwarm and K. Drauz, "The membrane reactor for the acylase process - from laboratory results to commercial scale", Chimica Oggi 1996, 14(10), 61-64;

  79. A.S. Bommarius, D.I.C. Wang and T.A. Hatton, "Xanthine Oxidase Reactivity in Reversed Micellar Systems: A Contribution to the Prediction of Enzymatic Activity in Organized Media", J. Amer. Chem. Soc. 1995, 117, 4515-4523;

  80. U. Joeres, A.S. Bommarius, J. Thömmes & M.-R. Kula, "Studies on the kinetics and application of L-carnitine amidase for production of L-carnitine", Biocatalysis & Biotransformation 1995, 12, 27-36;

  81. U. Eichhorn, A.S. Bommarius, K. Drauz and H.-D. Jakubke, "Environmentally acceptable synthesis of peptides in high yields by suspension-to-suspension conversion via protease catalysis", PEPTIDES 1994, (Hrsg.: H.L.S. Maia), Escom, Leiden, 1995, 226-7;

  82. T.A. Hatton and A.S. Bommarius, "A population balance analysis of substrate distribution effects on enzymatic reaction rates in reversed micelles", Proceedings of the Material Research Society 1995, 366, 439-444;

  83. A.S. Bommarius, M. Schwarm, K. Stingl, M. Kottenhahn, K. Huthmacher and K. Drauz, "Synthesis and Use of Enantiomerically Pure tert.-Leucine", Tetrahedron Asymmetry 1995, 6, 2851-2888;

  84. A. Fischer, A.S. Bommarius, K. Drauz and C. Wandrey, "A novel approach to enzymatic peptide synthesis using highly solubilizing Na-protecting groups of amino acids", Biocatalysis 1994, 8, 289-307;

  85. A.S. Bommarius, K. Drauz, W. Hummel, M.-R. Kula and C. Wandrey, "Some new developments in reductive amination with cofactor regeneration", Biocatalysis 1994, 10, 37-47;

  86. A.S. Bommarius and K. Drauz, "An Enzymatic Route to L-Ornithine from Arginine - Activation, Selectivity and Stabilization of L-Arginase", Bioorganic and Medicinal Chemistry 1994, 2, 617-626;

  87. C. Petit, A.S. Bommarius, M.-P. Pileni and T.A. Hatton, "Characterization of a Four-Component Cationic Reversed Micellar System: DTAC/Hexanol/n-Heptane/0.1 M KCl Solution", J. Phys.Chem. 1992, 96, 4653-58;

  88. A.S. Bommarius, K. Drauz, H. Klenk und C. Wandrey, "Operational Stability of Enzymes - Acylase-Catalyzed Resolution of N-Acetyl Amino Acids to Enantiomerically Pure L-Amino Acids", Annals N.Y. Acad. Sci. (Enzyme Eng. XI) 1992, 672, 126-36;

  89. A.S. Bommarius, M. Kottenhahn, H. Klenk and K. Drauz, "A versatile direct route from hydantoins to D-amino acids employing a resting cell biocatalyst with D-hydantoinase and D-carbamoylase activity", in: "Microbial Reagents in Organic Synthesis", ed.: S. Servi, Kluwer Acad. Publ., Dordrecht, London, Boston, NATO ASI Series 1992, C 381, 161-174;

  90. E.B. Leodidis, A.S. Bommarius and T.A. Hatton, "Amino Acids in Reversed Micelles: Dependence of the Interfacial Partition Coefficient on Excess Phase Salinity and Interfacial Curvature", J. Phys. Chem. 1991, 95, 5943-56;

  91. A.S. Bommarius, K. Makryaleas & K. Drauz, "An Enzymatic Route to L-Ornithine from L-Arginine; Activation and Stabilization Studies on L-Arginase", Biomed. Biochim. Acta 1991, 50, 249-55

  92. A. Fischer, A. Schwarz, C. Wandrey, A.S. Bommarius, G. Knaup and K. Drauz, "Preparative-scale enzyme-catalyzed peptide synthesis using solubilizing N-terminal protecting groups", Biomed. Biochim. Acta 1991, 50, 169-74

  93. A.S. Bommarius, J.F. Holzwarth, D.I.C. Wang & T.A. Hatton, "Coalescence and Solubilizate Exchange in a Cationic Four Component Reversed Micellar System", J. Phys. Chem. 1990, 94, 7232-39

  94. A.S. Bommarius, J.F. Holzwarth, D.I.C. Wang and T.A. Hatton, "A Population Balance Model for the Determination of Solubilizate Exchange Rate Constants in Reversed Micellar Systems", in: "Structure, Dynamics, and Equilibrium Properties in Colloidal Systems", NATO ASI Series C 1990, 324, 181-99, eds.: H.B. Bloor & E. Wyn-Jones, Kluwer Acad. Publ., Dordrecht, London, Boston

  95. J.W. Shield, H.D. Ferguson, A.S. Bommarius and T.A. Hatton, "Enzymes in Reversed Micelles as Catalysts for Organic-Phase Reactions"; Ind. Eng. Chem. Fundam. 1986, 25, 603-612